Deviance In Society Essay -- essays research papers

What does it mean to say, â€Å"deviance is socially defined?†   Ã‚  Ã‚  Ã‚  Ã‚  Deviance is defined as, â€Å"The recognized violation of cultural norms.† Deviance is an act of rebellion against set of rules, and expected behavior established by a certain society. Deviance is defined in many different ways. It is depended on the norms of the society, and region. Individuals become deviant when people label their actions as deviance. It depends on how that certain society defines deviance on individuals. The establishment of rules, and breaking rules in society is determined by strong social powers. This event leads to social inequality in society. â€Å"The Saints and the roughnecks†, are an example to labeling individuals as deviants, and it shows how social power causes inequality. Deviance appears in all likes of society. Deviance has many meanings to unconformity on a cultural norm. It depends on that the state of society, and its region. Prostitution is a profession that has existed since the beginning of society. Prostitution is viewed as a sleazy way of making money. The United States outlaws this profession, because it degrades females. Yet it is legal, and accepted in the city of Las Vegas, Nevada. Residents in Nevada view prostitution, as any other job.   Ã‚  Ã‚  Ã‚  Ã‚  Individuals become deviants when society decides to call the acts deviance. It is a labeling process put on the person. An example of deviant behavior would be the teen youth wearing ba...

Renissance and Reformation Essay -- Political, Economic, Social Develop

The arrival of the Renaissance in Europe brought many developments that led to an entirely new political, economic, and social structure. During the 1400s and 1500s, there was a major change that took place in all aspects of life in Italy. The Renaissance period of the 1500s was a time of artistic wonders of inspiration that emphasized individual achievements, which gave individuals their own ideals to follow. Inspiration from the ancient Greek and Roman people led to humanist beliefs and encouraged men to have achievements in many areas. Recovery from disasters of the fourteenth century such as the plague, political instability, and a decline in Church power led to interests in ancient culture. As interests grew, Renaissance arose in Italy for three reasons. First, Italy had several important cities, whereas most of northern Europe was still rural. Second, these cities included a class of wealthy and powerful merchants and bankers. Third, the ruined buildings and other reminders of classical Rome inspired Italian artists and scholars. The society also divided into three estates, or social classes. First estate was clergy, second was nobility, and third was commoners, which were peasants and townspeople. Also, marriages were arranged to strengthen political ties, and the humanism, new interest in the classical part, led to an important value in Renaissance. The ideals of the people changed . Italian writers, Machiavelli and Castiglione, began to create plays and other pieces of writing that did not hold back their true beliefs. Art, literature, math, and science greatly progressed due to humanism, and artworks became more realistic. Techniques such as fresco, developed by Masaccio, enabled the illusion of depth. Many other te... ... chief pillars were the Jesuits founded by the Ignatius of Loyola, reform of the papacy that happened in part to Protestantism, and Council of Trent that was a Reform Commission appointed in 1537 to determine Church’s ills and affirm traditional Catholic teachings. Then, Protestantism spread more the further it got from Rome. The arrival of the Renaissance in Europe brought many developments that led to an entirely new political, economic, and social structure, but it also brought a corruption in the Church. Inspiration from the ancient Greek and Roman people led to humanist beliefs and encouraged men to have achievements in many areas. The Church was no longer the center of life for many people, but it was still an important aspect. When it was brought to serious questions and political concerns, the Reformation caused Catholic responses in many areas of Europe.

The Worst Vacation Of My Life Essay -- Summer Vacation Essays

I used to spend the last part of my summer vacation with my uncle and aunt. As a continuation of a long-ago-established tradition we decided going to York - a small, picturesque tourist town at the seaside, located in the southeastern part of Maine. On the 27th of August, early in the morning we went to my uncle’s car with the entire luggage, prepared to leave and spend a nice, relaxing vacation, far away from the problems of the city. Unfortunately the unpleasant surprises started from the first second of our vacation. To our great disbelief the two front tires of the car were missing, and as later became clear, stolen during the night so at this moment the car was lying on the pavement, like a big wounded animal. I remember that my aunt said that this ought to be an omen of bad luck, warning not to go against your destiny and luck. After several hours repairing the car we, eventually, headed on, ready, for what turns to be the worst vacation in my entire life. However, our lack of luck was not over yet. On our way to the seaside we had a flat tire and after one more wasted hour searching for auto-service and proper repairment we were ready again. Unfortunately, our complete misfortune was still with us. Near Veliko Tirnovo the headway was closed, due to repair works, so we had to turn back a few kilometers and find another, this time not so good way. By this time the day was quickly turning into night. From the car windows I was seeing only the lights coming from the distant villages and the workers hurrying to get home. I thought for a moment, observing those people, that humans are very fragile. They were searching shelter from the coming night in those tiny lights, as they can save them from the perilous dark. ... ...one hospital I understood that she was lucky, because she had no other damages except 3 broken ribs and many bruises all over her body. That accident changed my prospective of seeing things. Long after the vacation I was feeling guilty because I had the chance of helping my aunt, but I failed. I was thinking that if I had not accepted her idea I might have prevented this. For the first time of my life I felt responsible for something. I discovered the meaning of the word â€Å"vulnerable†, and that made me even sicker. I was self-blaming for my inactivity and my helplessness. As the years pass I think that those memories are already left far in the past, that, slowly, I am surpassing them. But the changes are still visible- I am more cautious, knowing that every single moment is bringing certain risk and if I fail to notice it I may easily â€Å"fall from the cliff†.

Cause and Effect Solar Energy

Cause/Effect: Solar Energy Solar radiation is an energy resource many times larger than mankind’s energy needs. Mankind has been able to capture/harness this energy resource, but only on a limited scale. Mankind has found that the use of the sun was quite useful. They used it to grow and dry crops, dry clothing, produce heat, and for light. The sun is a sphere, on the inside of the sun there is a continuous process of fusion in which hydrogen nuclei combine to from helium nuclei. There is less helium than that of hydrogen, which allows the sun to create energy.The energy is then radiated out of the surface of the sun, in which only a small portion is intercepted by plant earth. Just outside of the earth’s atmosphere, approximately 93 million miles from the sun, has the intensity of radiation of about 1. 36 kilowatts per square foot. This process is also called the Solar Constant. This energy is absorbed, dispersed, and reflected by the atmosphere; beaming its radiation to earth’s ground. Almost half of this energy is visible light, approximately half is infrared radiation, and a very small portion of it is ultraviolet radiation.There are many ways to convert this energy. Some use it to heat their water and homes; some convert it to Electrical Energy. Most of the world’s energy needs have been met by converting solar energy into its electrical or mechanical forms. Electrical energy conversion of solar energy can be quite expensive. Much more than it would be to convert into thermal energy, but worth it in the long run. Solar panels or solar cells have been created to convert solar energy into mechanical energy, which can then be converted into electrical energy or used directly.This green energy alternative would cause a reduction in our environmental impact because it has less physical impact on the environment. They also help reduce the level of greenhouse gases produced and would decrease the demands of fossil fuels. Without a reli able, yet sustainable source of energy for the future, mankind will face a continued environmental destruction and continue to contribute to the growing problem of global warming. In order to stop the damage that is being done to the environment, we need to switch to an environmentally friendly energy production system.If we do not switch, the current facilities who rely mainly on fossil fuels, will continue to destroy the earth because they are leaving behind toxic residues and wasteful by products that will have to be dealt with for many years. The future lies with systems that eliminate these toxic and wasteful by products. Only by switching to fully renewable energy systems will humanity be free of these toxins. With our current technology and the expanding knowledge of tomorrow, wind turbines have a 30 year life span.The effort used to run these turbines is lower than the use of traditional power plants. Using wind energy to power turbines instead of plants using fossil fuels f or energy will reduce the overall impact of the U. S. Energy production. The before mentioned solar panel has a life expectancy of approximately 25 years. The total cost per kilowatt is way lower for solar panels than that of fossil fueled based power plants. These panels, once installed, need little to no maintenance. There is no monthly bill or added fees.Just like wind energy, solar energy is completely sustainable and they do not produce any physical by products. I believe that wind and solar energy is the perfect solution to the future of preserving the earth’s environment. Our environment is turning against us and there is a shortage of fossil fuels. It seems as though mankind as a whole is killing itself off. Mankind as a whole needs to rid itself of its dependency of fossil fuels. While wind and solar energy are not the only options available for sustainable energy solutions, in my opinion, they are the best alternative solutions.

Shanker’s Article on The Real Victims

Albert Shanker for 25 years was the columnist for â€Å"Where We Stand† in the New York Times and also president of the American Federation of Teachers. His article on the Real Victims addressed the need for alternative programs to resolve violence and disorder in schools. He agrees with Education reformers about setting high standards for students to achieve. But its worthless Shanker argues if students are continually in fear of a stray bullet hitting them or classes ruled by disruptive students. Shanker opens with an example of school violence, how it terrified one student witnessing the stabbing of another student. Fearful of herself being stabbed too, the girl dropped out of school but managed to earn a GED and further her education into college. Not many could follow the footsteps of this successful girl Shanker warns. Many students he states are scared and disarrayed and lost to school and learning. He gives an example of disruption and how if not equally more damaging it is when compared to school violence. If there is one student that is disruptive in a class then the teacher†s time will be spent on trying to contain this student rather than attend the many who want to learn Shanker states. As a consequence Shanker concludes this will wreck the concentration of the many learning students in that class. There is a high level of tolerance for this kind of behavior he states, and school officials seem to be at a loss. Shanker claims that students carrying guns or drugs or who have been violent to other students have simply been transferred to another school, and those students who are chronically disruptive seem to deserve more tolerance. He states that little is done to kids who keep others from learning. As a result of this failure to remedy the problem Shanker observes that parents that are very much aware of the situation go for vouchers and tuition tax credits. Hoping that by placing their children in schools that do not tolerate violence or disorderly conduct will shield them from it. Many education experts he points out argue that our first responsibility is to the minority of violent and disruptive kids. These kids they claim have a ‘right† to an education and that they deserve to stay in class too. He refutes this point by addressing the rights of the rest of the students making the majority of the class. Those he claims that are ready to work and willing to learn. Why he questions would we want to threaten their security and education. Shanker defends himself that he does not want to put the violent and disruptive children on the streets rather; he wants to see a change in the system. A system he urges that does not surrender the vast majority of willing and learning children for the few and violent children. A consequence of not finding an effective remedy to the system of things is that children with impressionable minds will learn the wrong lessons Shanker claims. To support his reasoning he gives an example of a child committing violence against another. The by-standers watching this happen are positive something bad will happen to this violent student. To the surprise of the children, the teacher gets in trouble for reporting the incidence. Children†s sense of right and wrong fades, a bad lesson taught and a violent child is automatically made a leader for the rest to observe and follow Shanker concedes. Shanker argues that the system is irrational and this is why irate parents demand vouchers and tax credits, anything that could save their children from the few violent children who take hostage the educational system. Rather than the majority of wiling and learning students move out, why not move the few aggressive and troublesome students, Shanker concludes.

Investigational New Drug Review Process

INVESTIGATIONAL NEW DRUG REVIEW PROCESS Investigational New Drug Review Process Prashanth Kumar Ponugoti Northeastern University INVESTIGATIONAL NEW DRUG REVIEW PROCESS Abstract Investigational New Drug (IND) review process begins from the time the sponsor files investigation new drug application and the purpose of the review is to confirm the safety and efficacy of the patient for the drug.Moreover in the process of review if the review committee notifies any deficiencies by the new drug then there will be a clinical however if there are no deficiencies the drug will be approved for new drug application and will be under continuous review to make sure , that the drug does not cause any potential harm. This entire step wise process of review is explained in the following paper INVESTIGATIONAL NEW DRUG REVIEW PROCESS The following flow chart gives an overview of the IND review process Applicant (Drug Sponsor)IND Review by CDER Statistical Pharmacology/ Toxicology Medical Chemistry Spo nsor Submits New Data Safety Review Safety acceptable for study to proceed Clinical Hold Decision Notify Sponsor Complete reviews Reviews Complete and Acceptable? Sponsor Notified of Deficiencies No Deficiencies Study Ongoing INVESTIGATIONAL NEW DRUG REVIEW PROCESS I. Applicant (Drug sponsor): An applicant or the sponsor is a person or a group who takes responsibility and initiates for the investigation of new drug.A person other than an individual that uses one or more of its own employees to conduct an investigation that it has initiated is a sponsor. The sponsor may be an individual, partnership, government agency, private agency, or any other organization and moreover the sponsor does not conduct the investigation process unless the sponsor is a sponsor-investigator. The applications are submitted to Center for Drug Evaluation and Research (CDER) Food and Drug Administration Document and Records Section 5901-B Ammendale Rd. Beltsville, Md. 20705-1266 II.Investigational New Drug Application: Sponsor thinks about new drug application when he has a successful results in preclinical studies (The studies conducted in animals to find the use of drug in human and ensure safety and efficacy) in other words it is the step taken after the successful preclinical studies to continue further studies that is clinical trial in humans. During the conduct of preclinical trial, step by step information of the process is recorded as data and stored. Thus stored information is helpful in filling an IND. The information is as follows A. Animal Pharmacology and toxicology studiesB. Manufacturing Information C. Clinical protocols and investigators information Animal Pharmacology and toxicology studies: The studies conducted in animals to ensure the use of the product is reasonably safe for initial testing in humans. Manufacturing Humans: This is the information obtained from manufacturing, storage, composition, storage and stability, for manufacturing of drug substance and produ ct. Clinical protocols and investigators information: protocols for proposed clinical studies to assess whether the initial-phase trials will expose subjects to unnecessary risks.Information on the qualifications of clinical investigators—professionals who oversee the administration of the experimental compound–to assess whether they are qualified to fulfill their clinical trial duties. The IND is not a marketing approval but The IND is the means through which the sponsor officially obtains this exemption from the FDA: however, its main intention is to detail the data that provide documentation that it is indeed reasonable to proceed with certain human trials with the drug. Types of INDs i. Investigator INDs ii. Emergency Use INDs and iii.Treatment IND After the submission of the IND to the Center for Drug Evaluation and Research (CDER) committee it checks thoroughly the medical, chemistry, toxicological, and statistical data INVESTIGATIONAL NEW DRUG REVIEW PROCESS The se terms are explained below in detail III. Medical Review: Medical also called as clinical review is conducted by medical officers or physicians to ensure the initial use of the drug in patients and are safe to use . This review is also conducted by the non medical officers based upon the data available from the re clinical studies.Medical review plays a major role in new drug review process and is an initiating step for the test of the drug in humans: however it is an important step to be conducted and based upon the results obtained from the review it has a further scope to apply for next steps that is to file new drug application. During this review process the medical reviewers or physicians evaluate the clinical trial protocol for to determine A. If the participants will be protected from unnecessary risks; and B. If the study design will provide data relevant to the safety and effectiveness of the drug.However the safety of the drug is taken by the sponsor during the phase I studies but during phase II, III, and IV Food and Drug Administration (FDA) must also ensure the safety of the medicament in humans for market approval. IV. Chemistry Review: Each review committee has an chemistry review department for reviewing the chemistry of the drug and the agenda of this chemistry department is to address issues related to drug identity, manufacturing control, and analysis. The reviewing committee ensures that the investigational new drug is adequately reproducible and stable.If the drug is neither adequately reproducible nor stable then the chances of approval for IND are less because they are not sure about the drugs action in the body, and don’t know what it does. So the major purpose of chemistry review is i. To ensure that the compound is adequately reproducible ii. To ensure that the compound is adequately stable In addition to this the sponsor should discuss any manufacturing and chemistry differences between the drug product proposed for the cli nical use and drug product used in animal toxicology studies.However these differences might affect the safety profile of the drug product and need to be stated if there are no differences. V. Pharmacology or Toxicology Review: This committee is a group of pharmacologists and toxicologists who evaluate the results of animal testing made during the clinical trial and compare it with the potential effects in humans. That is to ensure safety of the humans for the new drug. i. Pharmacology and Drug Distribution (21 CFR 312. 23(a)(8)(I)): This is nothing but absorption, distribution, metabolism and excretion of the drug in the animals.These results should be obtained by conducting them in animals, so it should be recorded with an example. Moreover this should not be a reason for the clinical hold because these rae the studies conducted in phase one of the IND and where FDA feels it as sponsor great responsibility factor for the drug in achieving safety and efficacy to the humans. ii. Tox icology Data (21 CFR 312. 23(a)(8)(ii)(a)): INVESTIGATIONAL NEW DRUG REVIEW PROCESS Toxicology data is required from both vitro and vivo studies, because particular studies depend upon nature of the drug and phase of human investigation.VI. Safety Review: After submission of the IND to the CDER then the committee takes about good 30 days to conduct review in every factor to achieve safety and efficacy and to avoid potential harm to the human. The review is an ongoing process however CDER notifies the sponsor immediately if there are any potential high risks associated with the drug upon usage in humans. If a notification is sent to sponsor then it is clear that the application is put on hold and the sponsor should conduct enough studies to clear the hold.This hold will be removed and allows the sponsor for further studies only when changes made to the clinical hold achieve the safety and efficacy and does not case potential risks. If the sponsor is not notified with any information from CDER from the day of IND submission to the 30 th day then on the 31st- day further study can be proceeded as submitted. VII. Clinical Hold Decision: The Clinical hold is issued in during the thirty day review period and this is due to the following factors 1. The drug causes potential harm to the humans 2.If drug is not having enough stability 3. The IND does not contain sufficient information required under 312. 23 to assess the risks to subjects of the proposed studies 4. The plan or protocol for the investigation is clearly deficient in design to meet its stated objectives. And CDER can hold the studies during the initial phases of the studies that is when filed for IND if observes potential risks on the data submitted initially. The Clinical hold will be removed if the sponsor addresses the issue based on the hold before the order is removed.In addition the clinical holds are reviewed by higher authorities of CDER to assure scientific quality and consistency in the Center's clinical hold decisions. IX. Notify Sponsor: X. Sponsor Notified of Deficiencies XI. Study Ongoing Xii. Conclusion†¦.. Page 17 and page 18 lo matter unnnadhi †¦ use gooogle search for material if required and provide the refrence where ever u grab the material†¦Ã¢â‚¬ ¦ Refrences: http://www. accessdata. fda. gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch. cfm? fr=312. 42 http://www. fda. gov/downloads/AboutFDA/CentersOffices/CDER/ManualofPoliciesProcedures/ucm082022. pdf

Partners Healthcare Case Question

Portfolio Theory Case (Professor David Moreno) PARTNERS HEALTHCARE CASE The goal of this case is to teach to students the relevance of non traditional assets (as real states or commodities) in a well-diversified portfolio. Moreover, students will be able to practice with the most important concepts from portfolio theory as efficient frontier, dominated portfolios, Sharpe ratio, among others. In addition, students are learning how portfolio theory can be useful not only for portfolio managers but for any company or firm with some funds to manage.To do this case students must work in groups and, at the end, each group must give a printed copy of the answers to all these questions. Moreover, they should prepare a presentation in Power Point or Word answering these questions for their presentation on the classroom. Short Questions (You should answer these questions very shortly) 1. How do the hospitals obtain their profits? Why do the hospitals use or need the Long-Term Funds? Compute th e annual returns obtained by the LTP between 1995 and 2004 and represent them on a graph.In addition, what has the average return been during that time period? 2. According to the text the physician organizations or hospitals can invest their financial resources in several centrally-managed pools. What are these pools? How are they? 1 Portfolio Theory Case (Professor David Moreno) 3. The problem presented in the case is a typical problem of portfolio theory. Is it a security selection problem or an asset allocation problem? Explain the differences among them. 4. During the last years the Parthners Investment Comitte have introduced a new asset class, REITs and Commodity Index.Explain these non traditional assets and if in your own opinion they should be interesting or not. Long Questions (in this case you will be considered a portfolio manager trying to explain or to answer to these question in a company or comitte, then use everything you need, computer, graphs, mathematics,†¦ ) 1. Suppose different hospitals within the Partners system choose different mixes of the â€Å"riskfree† STP and the baseline LTP, whose future expected returns and risks are shown in Exhibit 3.On Exhibit 3, plot the returns and risks of the various potential portfolios that can be formed by allocating funds between the STP and baseline LTP. What shape does a line drawn through these portfolios take? Why? 2. On Exhibit 5, plot the curve for the risks and expected returns of the optimal portfolio combinations in the 4 asset case detailed in Exhibit 6, namely: US Equities, Foreign Equities, Bonds, and REITs. Do the same for the 4 asset case shown in Exhibit 7: US, Foreign, Bonds, and Commodities.Do the same for the 5 asset case detailed in Exhibit 8: US, Foreign, Bonds, REITs, and Commodities. How much does each of the â€Å"real assets† improve the potential opportunities for the hospitals investing in the LTP? 3. About the results in the previous point: What are the i mportant factors that determine the degree of improvement when non traditional assets are introduced? 2 Portfolio Theory Case (Professor David Moreno) 4.Consider the hospital that wishes to invest in the STP and the LTP such that the total expected return on the portfolio is 6%. How does the introduction of real assets alter the risk and composition of their most attractive portfolio? 5. Consider the hospital that is fully invested in the LTP with its current standard deviation and wishes to maintain this level of risk. How much does the introduction of real assets help them, if at all? If it was needed consider the possibility of taking short positions. 3